This paper adds to the growing debate concerning the challenges of the United States strategic engagement strategy and recommends options for the emerging 21st Century. This author envisions a national interagency structure to integrate every instrument of national power. This structure will focus, collaborate and coordinate at four strategic levels: global, multi-regional, regional and national, and will implement three regional engagement strategy options. These are Conflict/Unilateral Operations, Support to Insurgencies and Security Assistance (SA) utilizing the principles of Foreign Internal Defense (FID) that will effectively facilitate the execution of the global war on terrorism (GWOT).